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Domestic Scheduled Flights
| Origin | Destination | Carier |
| CLT | AGS Augusta, GA | Air Midwest, Inc. |
| CLT | AHN Athens, GA | Air Midwest, Inc. |
| CLT | GSP Greer, SC | Air Midwest, Inc. |
| CLT | HKY Hickory, NC | Air Midwest, Inc. |
| CLT | HTS Huntington, WV | Air Midwest, Inc. |
| CLT | LEX Lexington, KY | Air Midwest, Inc. |
| CLT | LWB Lewisburg, WV | Air Midwest, Inc. |
| CLT | LYH Lynchburg, VA | Air Midwest, Inc. |
| CLT | SOP Southern Pines, NC | Air Midwest, Inc. |
| CLT | DCA Washington, DC, DC US | AirTran Airways |
| CLT | HOU Houston, TX US | AirTran Airways |
| CLT | MDW Chicago, IL US | AirTran Airways |
| CLT | TPA Tampa, FL US | AirTran Airways |
| CLT | DAL Dallas, TX US | American Airlines |
| CLT | DFW Dallas / Ft Worth, TX US | American Airlines |
| CLT | HOU Houston, TX US | American Airlines |
| CLT | ORD Chicago, IL US | American Airlines |
| CLT | MDW Chicago, IL US | ATA Airlines |
| CLT | BDL Windsor Locks, CT | Atlantic Coast Airlines |
| CLT | BNA Nashville, TN | Atlantic Coast Airlines |
| CLT | BUF Buffalo, NY | Atlantic Coast Airlines |
| CLT | CAK Akron/Canton, OH | Atlantic Coast Airlines |
| CLT | FAR Fargo, ND | Atlantic Coast Airlines |
| CLT | FSD Sioux Falls, SD | Atlantic Coast Airlines |
| CLT | GRR Grand Rapids, MI | Atlantic Coast Airlines |
| CLT | MBS Saginaw, MI | Atlantic Coast Airlines |
| CLT | MSN Madison, WI | Atlantic Coast Airlines |
| CLT | OKC Oklahoma City, OK | Atlantic Coast Airlines |
| CLT | ORD Chicago, IL | Atlantic Coast Airlines |
| CLT | ROC Rochester, NY | Atlantic Coast Airlines |
| CLT | TUL Tulsa, OK | Atlantic Coast Airlines |
| CLT | AGS Augusta, GA | CCair |
| CLT | AHN Athens, GA | CCair |
| CLT | CVG Cincinnati, OH | CCair |
| CLT | HKY Hickory, NC | CCair |
| CLT | LEX Lexington, KY | CCair |
| CLT | LWB Lewisburg, WV | CCair |
| CLT | OAJ Jacksonville, NC | CCair |
| CLT | PGV Greenville, NC | CCair |
| CLT | RDU Raleigh/Durham, NC | CCair |
| CLT | SOP Southern Pines, NC | CCair |
| CLT | TLH Tallahassee, FL | CCair |
| CLT | IAD Washington, DC | Colgan Air |
| CLT | DAL Dallas, TX US | Continental Airlines |
| CLT | EWR Newark, NJ US | Continental Airlines |
| CLT | IAH Houston, TX US | Continental Airlines |
| CLT | DCA Washington, DC, DC US | Delta Air Lines |
| CLT | HOU Houston, TX US | Delta Air Lines |
| CLT | LGA New York City, NY US | Delta Air Lines |
| CLT | MDW Chicago, IL US | Delta Air Lines |
| CLT | IAD Washington, DC, DC US | Independence Air |
| CLT | JFK New York City, NY US | Independence Air |
| CLT | JFK New York City, NY US | JetBlue Airways |
| CLT | AGS Augusta, GA | Mesa Airlines, Inc. |
| CLT | ATL Atlanta, GA | Mesa Airlines, Inc. |
| CLT | BHM Birmingham, AL | Mesa Airlines, Inc. |
| CLT | BTR Baton Rouge, LA | Mesa Airlines, Inc. |
| CLT | CAE Columbia, SC | Mesa Airlines, Inc. |
| CLT | CHA Chattanooga, TN | Mesa Airlines, Inc. |
| CLT | CRW Charleston, WV | Mesa Airlines, Inc. |
| CLT | CVG Cincinnati, OH | Mesa Airlines, Inc. |
| CLT | DAY Dayton, OH | Mesa Airlines, Inc. |
| CLT | DCA Washington, DC | Mesa Airlines, Inc. |
| CLT | FAY Fayetteville, NC | Mesa Airlines, Inc. |
| CLT | GSO Greensboro/High Point, NC | Mesa Airlines, Inc. |
| CLT | GSP Greer, SC | Mesa Airlines, Inc. |
| CLT | HSV Huntsville, AL | Mesa Airlines, Inc. |
| CLT | JAN Jackson, MS | Mesa Airlines, Inc. |
| CLT | LEX Lexington, KY | Mesa Airlines, Inc. |
| CLT | LIT Little Rock, AR | Mesa Airlines, Inc. |
| CLT | MEM Memphis, TN | Mesa Airlines, Inc. |
| CLT | MGM Montgomery, AL | Mesa Airlines, Inc. |
| CLT | MOB Mobile, AL | Mesa Airlines, Inc. |
| CLT | OAJ Jacksonville, NC | Mesa Airlines, Inc. |
| CLT | PGV Greenville, NC | Mesa Airlines, Inc. |
| CLT | RDU Raleigh/Durham, NC | Mesa Airlines, Inc. |
| CLT | RIC Richmond, VA | Mesa Airlines, Inc. |
| CLT | ROA Roanoke, VA | Mesa Airlines, Inc. |
| CLT | TLH Tallahassee, FL | Mesa Airlines, Inc. |
| CLT | TYS Knoxville, TN | Mesa Airlines, Inc. |
| CLT | XNA Fayetteville, AR | Mesa Airlines, Inc. |
| CLT | MDW Chicago, IL US | Northwest Airlines |
| CLT | AVL Asheville, NC | Piedmont Airlines |
| CLT | BWI Baltimore, MD | Piedmont Airlines |
| CLT | CAE Columbia, SC | Piedmont Airlines |
| CLT | CHA Chattanooga, TN | Piedmont Airlines |
| CLT | CHO Charlottesville, VA | Piedmont Airlines |
| CLT | CHS Charleston, SC | Piedmont Airlines |
| CLT | CRW Charleston, WV | Piedmont Airlines |
| CLT | CSG Columbus, GA | Piedmont Airlines |
| CLT | DAY Dayton, OH | Piedmont Airlines |
| CLT | DCA Washington, DC | Piedmont Airlines |
| CLT | EWN New Bern, NC | Piedmont Airlines |
| CLT | EYW Key West, FL | Piedmont Airlines |
| CLT | FAY Fayetteville, NC | Piedmont Airlines |
| CLT | FLO Florence, SC | Piedmont Airlines |
| CLT | GNV Gainesville, FL | Piedmont Airlines |
| CLT | GSO Greensboro/High Point, NC | Piedmont Airlines |
| CLT | GSP Greer, SC | Piedmont Airlines |
| CLT | HHH Hilton Head Island, SC | Piedmont Airlines |
| CLT | ILM Wilmington, NC | Piedmont Airlines |
| CLT | JAX Jacksonville, FL | Piedmont Airlines |
| CLT | MCO Orlando, FL | Piedmont Airlines |
| CLT | MGM Montgomery, AL | Piedmont Airlines |
| CLT | MIA Miami, FL | Piedmont Airlines |
| CLT | ORF Norfolk, VA | Piedmont Airlines |
| CLT | PHF Newport News, VA | Piedmont Airlines |
| CLT | PHL Philadelphia, PA | Piedmont Airlines |
| CLT | PIT Pittsburgh, PA | Piedmont Airlines |
| CLT | RDU Raleigh/Durham, NC | Piedmont Airlines |
| CLT | ROA Roanoke, VA | Piedmont Airlines |
| CLT | SAV Savannah, GA | Piedmont Airlines |
| CLT | SBY Salisbury, MD | Piedmont Airlines |
| CLT | TPA Tampa, FL | Piedmont Airlines |
| CLT | TRI Kingsport, TN | Piedmont Airlines |
| CLT | TYS Knoxville, TN | Piedmont Airlines |
| CLT | CAK Akron/Canton, OH | PSA Airlines, Inc. |
| CLT | DAY Dayton, OH | PSA Airlines, Inc. |
| CLT | DCA Washington, DC | PSA Airlines, Inc. |
| CLT | PHL Philadelphia, PA | PSA Airlines, Inc. |
| CLT | PIT Pittsburgh, PA | PSA Airlines, Inc. |
| CLT | RDU Raleigh/Durham, NC | PSA Airlines, Inc. |
| CLT | RIC Richmond, VA | PSA Airlines, Inc. |
| CLT | TRI Kingsport, TN | PSA Airlines, Inc. |
| CLT | TYS Knoxville, TN | PSA Airlines, Inc. |
| CLT | IAD Washington, DC, DC US | United Airlines |
| CLT | LGA New York City, NY US | United Airlines |
| CLT | ORD Chicago, IL US | United Airlines |
| CLT | TPA Tampa, FL US | United Airlines |
| CLT | DCA Washington, DC, DC US | US Airways |
| CLT | DFW Dallas / Ft Worth, TX US | US Airways |
| CLT | EWR Newark, NJ US | US Airways |
| CLT | IAD Washington, DC, DC US | US Airways |
| CLT | IAH Houston, TX US | US Airways |
| CLT | LGA New York City, NY US | US Airways |
| CLT | TPA Tampa, FL US | US Airways |
| CLT | GCM Claremore, OK US | US Airways |
| CLT | SJU San Juan, PR US | US Airways |
| CLT | STT Charlotte Amalie St Thomas, VI US | US Airways |
| CLT | STX Christiansted St Croix, VI US | US Airways |
There is over 140 domestic flights from CLT airport.
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