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Domestic Scheduled Flights
| Origin | Destination | Carier |
| GSO | ALB Albany, NY | Allegheny Airlines |
| GSO | BUF Buffalo, NY | Allegheny Airlines |
| GSO | BWI Baltimore, MD | Allegheny Airlines |
| GSO | LGA New York, NY | Allegheny Airlines |
| GSO | ROC Rochester, NY | Allegheny Airlines |
| GSO | SYR Syracuse, NY | Allegheny Airlines |
| GSO | HOU Houston, TX US | American Airlines |
| GSO | DFW Dallas / Ft Worth, TX US | American Airlines |
| GSO | ORD Chicago, IL US | American Airlines |
| GSO | ABE Allentown, PA | Atlantic Coast Airlines |
| GSO | ALB Albany, NY | Atlantic Coast Airlines |
| GSO | BDL Windsor Locks, CT | Atlantic Coast Airlines |
| GSO | BGM Binghamton, NY | Atlantic Coast Airlines |
| GSO | BHM Birmingham, AL | Atlantic Coast Airlines |
| GSO | BNA Nashville, TN | Atlantic Coast Airlines |
| GSO | BTV Burlington, VT | Atlantic Coast Airlines |
| GSO | BUF Buffalo, NY | Atlantic Coast Airlines |
| GSO | CHO Charlottesville, VA | Atlantic Coast Airlines |
| GSO | CHS Charleston, SC | Atlantic Coast Airlines |
| GSO | CLE Cleveland, OH | Atlantic Coast Airlines |
| GSO | CMH Columbus, OH | Atlantic Coast Airlines |
| GSO | CRW Charleston, WV | Atlantic Coast Airlines |
| GSO | DAY Dayton, OH | Atlantic Coast Airlines |
| GSO | DSM Des Moines, IA | Atlantic Coast Airlines |
| GSO | DTW Detroit, MI | Atlantic Coast Airlines |
| GSO | EWR Newark, NJ | Atlantic Coast Airlines |
| GSO | FAR Fargo, ND | Atlantic Coast Airlines |
| GSO | FSD Sioux Falls, SD | Atlantic Coast Airlines |
| GSO | FWA Fort Wayne, IN | Atlantic Coast Airlines |
| GSO | GRR Grand Rapids, MI | Atlantic Coast Airlines |
| GSO | HPN White Plains, NY | Atlantic Coast Airlines |
| GSO | IAD Washington, DC | Atlantic Coast Airlines |
| GSO | ICT Wichita, KS | Atlantic Coast Airlines |
| GSO | IND Indianapolis, IN | Atlantic Coast Airlines |
| GSO | JAX Jacksonville, FL | Atlantic Coast Airlines |
| GSO | JFK New York, NY | Atlantic Coast Airlines |
| GSO | LAN Lansing, MI | Atlantic Coast Airlines |
| GSO | LEX Lexington, KY | Atlantic Coast Airlines |
| GSO | LGA New York, NY | Atlantic Coast Airlines |
| GSO | MBS Saginaw, MI | Atlantic Coast Airlines |
| GSO | MDT Harrisburg, PA | Atlantic Coast Airlines |
| GSO | MEM Memphis, TN | Atlantic Coast Airlines |
| GSO | MHT Manchester, NH | Atlantic Coast Airlines |
| GSO | MLI Moline, IL | Atlantic Coast Airlines |
| GSO | OKC Oklahoma City, OK | Atlantic Coast Airlines |
| GSO | ORD Chicago, IL | Atlantic Coast Airlines |
| GSO | ORF Norfolk, VA | Atlantic Coast Airlines |
| GSO | PHL Philadelphia, PA | Atlantic Coast Airlines |
| GSO | PIT Pittsburgh, PA | Atlantic Coast Airlines |
| GSO | PVD Providence, RI | Atlantic Coast Airlines |
| GSO | PWM Portland, ME | Atlantic Coast Airlines |
| GSO | RDU Raleigh/Durham, NC | Atlantic Coast Airlines |
| GSO | RIC Richmond, VA | Atlantic Coast Airlines |
| GSO | ROA Roanoke, VA | Atlantic Coast Airlines |
| GSO | ROC Rochester, NY | Atlantic Coast Airlines |
| GSO | SAV Savannah, GA | Atlantic Coast Airlines |
| GSO | SBN South Bend, IN | Atlantic Coast Airlines |
| GSO | SCE State College, PA | Atlantic Coast Airlines |
| GSO | SDF Louisville, KY | Atlantic Coast Airlines |
| GSO | SGF Springfield, MO | Atlantic Coast Airlines |
| GSO | SWF Newburgh, NY | Atlantic Coast Airlines |
| GSO | SYR Syracuse, NY | Atlantic Coast Airlines |
| GSO | TUL Tulsa, OK | Atlantic Coast Airlines |
| GSO | TVC Traverse City, MI | Atlantic Coast Airlines |
| GSO | BOS Boston, MA | Chautauqua Airlines, Inc. |
| GSO | BUF Buffalo, NY | Chautauqua Airlines, Inc. |
| GSO | CHS Charleston, SC | Chautauqua Airlines, Inc. |
| GSO | DAY Dayton, OH | Chautauqua Airlines, Inc. |
| GSO | LGA New York, NY | Chautauqua Airlines, Inc. |
| GSO | RDU Raleigh/Durham, NC | Chautauqua Airlines, Inc. |
| GSO | RIC Richmond, VA | Chautauqua Airlines, Inc. |
| GSO | ROC Rochester, NY | Chautauqua Airlines, Inc. |
| GSO | EWR Newark, NJ US | Continental Airlines |
| GSO | IAH Houston, TX US | Continental Airlines |
| GSO | DAL Dallas, TX US | Continental Airlines |
| GSO | HOU Houston, TX US | Delta Air Lines |
| GSO | JFK New York City, NY US | Delta Air Lines |
| GSO | LGA New York City, NY US | Delta Air Lines |
| GSO | TPA Tampa, FL US | Delta Air Lines |
| GSO | MDW Chicago, IL US | Delta Air Lines |
| GSO | EWR Newark, NJ US | Independence Air |
| GSO | IAD Washington, DC, DC US | Independence Air |
| GSO | JFK New York City, NY US | Independence Air |
| GSO | TPA Tampa, FL US | Independence Air |
| GSO | ORD Chicago, IL US | Independence Air |
| GSO | CLT Charlotte, NC | Mesa Airlines, Inc. |
| GSO | PHL Philadelphia, PA | Mesa Airlines, Inc. |
| GSO | PIT Pittsburgh, PA | Mesa Airlines, Inc. |
| GSO | MDW Chicago, IL US | Northwest Airlines |
| GSO | ALB Albany, NY | Piedmont Airlines |
| GSO | AVL Asheville, NC | Piedmont Airlines |
| GSO | BWI Baltimore, MD | Piedmont Airlines |
| GSO | CAE Columbia, SC | Piedmont Airlines |
| GSO | CHA Chattanooga, TN | Piedmont Airlines |
| GSO | CHO Charlottesville, VA | Piedmont Airlines |
| GSO | CLT Charlotte, NC | Piedmont Airlines |
| GSO | CRW Charleston, WV | Piedmont Airlines |
| GSO | CSG Columbus, GA | Piedmont Airlines |
| GSO | DCA Washington, DC | Piedmont Airlines |
| GSO | EWN New Bern, NC | Piedmont Airlines |
| GSO | FAY Fayetteville, NC | Piedmont Airlines |
| GSO | FLO Florence, SC | Piedmont Airlines |
| GSO | GNV Gainesville, FL | Piedmont Airlines |
| GSO | GSP Greer, SC | Piedmont Airlines |
| GSO | HHH Hilton Head Island, SC | Piedmont Airlines |
| GSO | HPN White Plains, NY | Piedmont Airlines |
| GSO | IAD Washington, DC | Piedmont Airlines |
| GSO | ILM Wilmington, NC | Piedmont Airlines |
| GSO | JAX Jacksonville, FL | Piedmont Airlines |
| GSO | MGM Montgomery, AL | Piedmont Airlines |
| GSO | MHT Manchester, NH | Piedmont Airlines |
| GSO | ORF Norfolk, VA | Piedmont Airlines |
| GSO | PHF Newport News, VA | Piedmont Airlines |
| GSO | PHL Philadelphia, PA | Piedmont Airlines |
| GSO | RDU Raleigh/Durham, NC | Piedmont Airlines |
| GSO | SBY Salisbury, MD | Piedmont Airlines |
| GSO | TPA Tampa, FL | Piedmont Airlines |
| GSO | TRI Kingsport, TN | Piedmont Airlines |
| GSO | TYS Knoxville, TN | Piedmont Airlines |
| GSO | CAK Akron/Canton, OH | PSA Airlines, Inc. |
| GSO | CVG Cincinnati, OH | PSA Airlines, Inc. |
| GSO | ELM Elmira, NY | PSA Airlines, Inc. |
| GSO | EVV Evansville, IN | PSA Airlines, Inc. |
| GSO | PIT Pittsburgh, PA | PSA Airlines, Inc. |
| GSO | SBN South Bend, IN | PSA Airlines, Inc. |
| GSO | DFW Dallas/Fort Worth, TX | Sky West Airlines, Inc. |
| GSO | OKC Oklahoma City, OK | Sky West Airlines, Inc. |
| GSO | SHV Shreveport, LA | Sky West Airlines, Inc. |
| GSO | IAD Washington, DC, DC US | United Airlines |
| GSO | JFK New York City, NY US | United Airlines |
| GSO | ORD Chicago, IL US | United Airlines |
| GSO | DCA Washington, DC, DC US | US Airways |
| GSO | IAH Houston, TX US | US Airways |
| GSO | LGA New York City, NY US | US Airways |
| GSO | TPA Tampa, FL US | US Airways |
| GSO | DFW Dallas / Ft Worth, TX US | US Airways |
There is over 136 domestic flights from GSO airport.
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