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Domestic Scheduled Flights
| Origin | Destination | Carier |
| LSE | DCA Washington, DC, DC US | American Airlines |
| LSE | EWR Newark, NJ US | American Airlines |
| LSE | IAD Washington, DC, DC US | American Airlines |
| LSE | JFK New York City, NY US | American Airlines |
| LSE | LGA New York City, NY US | American Airlines |
| LSE | TPA Tampa, FL US | American Airlines |
| LSE | ORD Chicago, IL US | American Airlines |
| LSE | ATW Appleton, WI | Astral Aviation |
| LSE | BDL Windsor Locks, CT | Astral Aviation |
| LSE | BNA Nashville, TN | Astral Aviation |
| LSE | BWI Baltimore, MD | Astral Aviation |
| LSE | CLE Cleveland, OH | Astral Aviation |
| LSE | CMH Columbus, OH | Astral Aviation |
| LSE | CVG Cincinnati, OH | Astral Aviation |
| LSE | DAY Dayton, OH | Astral Aviation |
| LSE | DSM Des Moines, IA | Astral Aviation |
| LSE | ESC Escanaba, MI | Astral Aviation |
| LSE | FNT Flint, MI | Astral Aviation |
| LSE | GRB Green Bay, WI | Astral Aviation |
| LSE | GRR Grand Rapids, MI | Astral Aviation |
| LSE | IAD Washington, DC | Astral Aviation |
| LSE | IND Indianapolis, IN | Astral Aviation |
| LSE | LAN Lansing, MI | Astral Aviation |
| LSE | MKE Milwaukee, WI | Astral Aviation |
| LSE | MKG Muskegon, MI | Astral Aviation |
| LSE | MLI Moline, IL | Astral Aviation |
| LSE | MQT Marquette, MI | Astral Aviation |
| LSE | MSN Madison, WI | Astral Aviation |
| LSE | PHL Philadelphia, PA | Astral Aviation |
| LSE | PIT Pittsburgh, PA | Astral Aviation |
| LSE | RDU Raleigh/Durham, NC | Astral Aviation |
| LSE | SDF Louisville, KY | Astral Aviation |
| LSE | STL St. Louis, MO | Astral Aviation |
| LSE | DCA Washington, DC, DC US | Midwest Airlines |
| LSE | TPA Tampa, FL US | Midwest Airlines |
| LSE | DCA Washington, DC, DC US | Northwest Airlines |
| LSE | EWR Newark, NJ US | Northwest Airlines |
| LSE | IAD Washington, DC, DC US | Northwest Airlines |
| LSE | JFK New York City, NY US | Northwest Airlines |
| LSE | LGA New York City, NY US | Northwest Airlines |
| LSE | TPA Tampa, FL US | Northwest Airlines |
| LSE | DFW Dallas / Ft Worth, TX US | Northwest Airlines |
| LSE | MDW Chicago, IL US | Northwest Airlines |
There is over 43 domestic flights from LSE airport.
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