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Domestic Scheduled Flights
| Origin | Destination | Carier |
| SMX | CLD Carlsbad, CA | Sky West Airlines, Inc. |
| SMX | COS Colorado Springs, CO | Sky West Airlines, Inc. |
| SMX | FAT Fresno, CA | Sky West Airlines, Inc. |
| SMX | IPL El Centro, CA | Sky West Airlines, Inc. |
| SMX | IYK Inyokern, CA | Sky West Airlines, Inc. |
| SMX | LAX Los Angeles, CA | Sky West Airlines, Inc. |
| SMX | MRY Monterey, CA | Sky West Airlines, Inc. |
| SMX | OAK Oakland, CA | Sky West Airlines, Inc. |
| SMX | ONT Ontario, CA | Sky West Airlines, Inc. |
| SMX | PHX Phoenix, AZ | Sky West Airlines, Inc. |
| SMX | PSP Palm Springs, CA | Sky West Airlines, Inc. |
| SMX | SAN San Diego, CA | Sky West Airlines, Inc. |
| SMX | SGU St. George, UT | Sky West Airlines, Inc. |
| SMX | SJC San Jose, CA | Sky West Airlines, Inc. |
| SMX | SMF Sacramento, CA | Sky West Airlines, Inc. |
| SMX | SNA Santa Ana, CA | Sky West Airlines, Inc. |
| SMX | TUS Tucson, AZ | Sky West Airlines, Inc. |
| SMX | VIS Visalia, CA | Sky West Airlines, Inc. |
| SMX | YUM Yuma, AZ | Sky West Airlines, Inc. |
| SMX | DCA Washington, DC, DC US | United Airlines |
| SMX | IAD Washington, DC, DC US | United Airlines |
There is over 21 domestic flights from SMX airport.
