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Domestic Scheduled Flights
| Origin | Destination | Carier |
| SNA | DCA Washington, DC, DC US | America West Airlines |
| SNA | IAH Houston, TX US | America West Airlines |
| SNA | JFK New York City, NY US | America West Airlines |
| SNA | DCA Washington, DC, DC US | American Airlines |
| SNA | IAD Washington, DC, DC US | American Airlines |
| SNA | DFW Dallas / Ft Worth, TX US | American Airlines |
| SNA | EWR Newark, NJ US | American Airlines |
| SNA | IAH Houston, TX US | American Airlines |
| SNA | JFK New York City, NY US | American Airlines |
| SNA | LGA New York City, NY US | American Airlines |
| SNA | ORD Chicago, IL US | American Airlines |
| SNA | TPA Tampa, FL US | Continental Airlines |
| SNA | DAL Dallas, TX US | Continental Airlines |
| SNA | EWR Newark, NJ US | Continental Airlines |
| SNA | IAH Houston, TX US | Continental Airlines |
| SNA | DCA Washington, DC, DC US | Delta Air Lines |
| SNA | TPA Tampa, FL US | Delta Air Lines |
| SNA | JFK New York City, NY US | Delta Air Lines |
| SNA | LGA New York City, NY US | Delta Air Lines |
| SNA | MDW Chicago, IL US | Frontier Airlines |
| SNA | ICT Wichita, KS | Mesa Airlines, Inc. |
| SNA | MRY Monterey, CA | Mesa Airlines, Inc. |
| SNA | PHX Phoenix, AZ | Mesa Airlines, Inc. |
| SNA | SAT San Antonio, TX | Mesa Airlines, Inc. |
| SNA | ACV Arcata, CA | Sky West Airlines, Inc. |
| SNA | BFL Bakersfield, CA | Sky West Airlines, Inc. |
| SNA | BOI Boise, ID | Sky West Airlines, Inc. |
| SNA | CEC Crescent City, CA | Sky West Airlines, Inc. |
| SNA | CLD Carlsbad, CA | Sky West Airlines, Inc. |
| SNA | COS Colorado Springs, CO | Sky West Airlines, Inc. |
| SNA | DEN Denver, CO | Sky West Airlines, Inc. |
| SNA | FAT Fresno, CA | Sky West Airlines, Inc. |
| SNA | IPL El Centro, CA | Sky West Airlines, Inc. |
| SNA | IYK Inyokern, CA | Sky West Airlines, Inc. |
| SNA | LAS Las Vegas, NV | Sky West Airlines, Inc. |
| SNA | LAX Los Angeles, CA | Sky West Airlines, Inc. |
| SNA | MRY Monterey, CA | Sky West Airlines, Inc. |
| SNA | OAK Oakland, CA | Sky West Airlines, Inc. |
| SNA | OXR Oxnard, CA | Sky West Airlines, Inc. |
| SNA | PHX Phoenix, AZ | Sky West Airlines, Inc. |
| SNA | PSP Palm Springs, CA | Sky West Airlines, Inc. |
| SNA | SAN San Diego, CA | Sky West Airlines, Inc. |
| SNA | SBA Santa Barbara, CA | Sky West Airlines, Inc. |
| SNA | SBP San Luis Obispo, CA | Sky West Airlines, Inc. |
| SNA | SFO San Francisco, CA | Sky West Airlines, Inc. |
| SNA | SGU St. George, UT | Sky West Airlines, Inc. |
| SNA | SJC San Jose, CA | Sky West Airlines, Inc. |
| SNA | SLC Salt Lake City, UT | Sky West Airlines, Inc. |
| SNA | SMF Sacramento, CA | Sky West Airlines, Inc. |
| SNA | SMX Santa Maria, CA | Sky West Airlines, Inc. |
| SNA | TUS Tucson, AZ | Sky West Airlines, Inc. |
| SNA | VIS Visalia, CA | Sky West Airlines, Inc. |
| SNA | YUM Yuma, AZ | Sky West Airlines, Inc. |
| SNA | DAL Dallas, TX US | Southwest Airlines |
| SNA | HOU Houston, TX US | Southwest Airlines |
| SNA | MDW Chicago, IL US | Southwest Airlines |
| SNA | IAD Washington, DC, DC US | United Airlines |
| SNA | LGA New York City, NY US | United Airlines |
There is over 58 domestic flights from SNA airport.
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