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Domestic Scheduled Flights
| Origin | Destination | Carier |
| RSW | DCA Washington, DC, DC US | AirTran Airways |
| RSW | HOU Houston, TX US | AirTran Airways |
| RSW | IAD Washington, DC, DC US | AirTran Airways |
| RSW | MDW Chicago, IL US | AirTran Airways |
| RSW | IAH Houston, TX US | American Airlines |
| RSW | LGA New York City, NY US | American Airlines |
| RSW | DFW Dallas / Ft Worth, TX US | American Airlines |
| RSW | MDW Chicago, IL US | ATA Airlines |
| RSW | EYW Key West, FL | Cape Air |
| RSW | EWR Newark, NJ US | Continental Airlines |
| RSW | IAH Houston, TX US | Continental Airlines |
| RSW | DAL Dallas, TX US | Continental Airlines |
| RSW | JFK New York City, NY US | Delta Air Lines |
| RSW | LGA New York City, NY US | Delta Air Lines |
| RSW | MDW Chicago, IL US | Delta Air Lines |
| RSW | DAB Daytona Beach, FL | Gulfstream International Airlines |
| RSW | EYW Key West, FL | Gulfstream International Airlines |
| RSW | FLL Fort Lauderdale, FL | Gulfstream International Airlines |
| RSW | MCO Orlando, FL | Gulfstream International Airlines |
| RSW | MIA Miami, FL | Gulfstream International Airlines |
| RSW | MLB Melbourne, FL | Gulfstream International Airlines |
| RSW | TPA Tampa, FL | Gulfstream International Airlines |
| RSW | IAD Washington, DC, DC US | Independence Air |
| RSW | EWR Newark, NJ US | JetBlue Airways |
| RSW | JFK New York City, NY US | JetBlue Airways |
| RSW | CMH Columbus, OH | Mesa Airlines, Inc. |
| RSW | ORD Chicago, IL | Mesa Airlines, Inc. |
| RSW | PHL Philadelphia, PA | Mesa Airlines, Inc. |
| RSW | MCO Orlando, FL | Sky West Airlines, Inc. |
| RSW | HOU Houston, TX US | Southwest Airlines |
| RSW | DAL Dallas, TX US | Southwest Airlines |
| RSW | MDW Chicago, IL US | Southwest Airlines |
| RSW | ORD Chicago, IL US | Spirit Airlines |
| RSW | IAD Washington, DC, DC US | United Airlines |
| RSW | DCA Washington, DC, DC US | US Airways |
There is over 35 domestic flights from RSW airport.
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