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Domestic Scheduled Flights
| Origin | Destination | Carier |
| PNS | JAX Jacksonville, FL | Air Midwest, Inc. |
| PNS | MSY New Orleans, LA | Air Midwest, Inc. |
| PNS | SHV Shreveport, LA | Air Midwest, Inc. |
| PNS | TLH Tallahassee, FL | Air Midwest, Inc. |
| PNS | DCA Washington, DC, DC US | AirTran Airways |
| PNS | IAD Washington, DC, DC US | AirTran Airways |
| PNS | TPA Tampa, FL US | AirTran Airways |
| PNS | DFW Dallas / Ft Worth, TX US | AirTran Airways |
| PNS | EWR Newark, NJ US | AirTran Airways |
| PNS | HOU Houston, TX US | AirTran Airways |
| PNS | LGA New York City, NY US | AirTran Airways |
| PNS | MDW Chicago, IL US | AirTran Airways |
| PNS | DFW Dallas / Ft Worth, TX US | American Airlines |
| PNS | IAH Houston, TX US | American Airlines |
| PNS | ORD Chicago, IL US | American Airlines |
| PNS | DAL Dallas, TX US | Continental Airlines |
| PNS | IAH Houston, TX US | Continental Airlines |
| PNS | DCA Washington, DC, DC US | Delta Air Lines |
| PNS | IAD Washington, DC, DC US | Delta Air Lines |
| PNS | TPA Tampa, FL US | Delta Air Lines |
| PNS | DFW Dallas / Ft Worth, TX US | Delta Air Lines |
| PNS | EWR Newark, NJ US | Delta Air Lines |
| PNS | JFK New York City, NY US | Delta Air Lines |
| PNS | LGA New York City, NY US | Delta Air Lines |
| PNS | ORD Chicago, IL US | Delta Air Lines |
| PNS | AEX Alexandria, LA | Express Airlines |
| PNS | ATW Appleton, WI | Express Airlines |
| PNS | BHM Birmingham, AL | Express Airlines |
| PNS | BTR Baton Rouge, LA | Express Airlines |
| PNS | BTV Burlington, VT | Express Airlines |
| PNS | CAK Akron/Canton, OH | Express Airlines |
| PNS | CHA Chattanooga, TN | Express Airlines |
| PNS | CMH Columbus, OH | Express Airlines |
| PNS | DSM Des Moines, IA | Express Airlines |
| PNS | DTW Detroit, MI | Express Airlines |
| PNS | ERI Erie, PA | Express Airlines |
| PNS | EVV Evansville, IN | Express Airlines |
| PNS | FSM Fort Smith, AR | Express Airlines |
| PNS | GLH Greenville, MS | Express Airlines |
| PNS | GSP Greer, SC | Express Airlines |
| PNS | GTR Columbus, MS | Express Airlines |
| PNS | HSV Huntsville, AL | Express Airlines |
| PNS | ICT Wichita, KS | Express Airlines |
| PNS | JLN Joplin, MO | Express Airlines |
| PNS | LEX Lexington, KY | Express Airlines |
| PNS | LFT Lafayette, LA | Express Airlines |
| PNS | MEI Meridian, MS | Express Airlines |
| PNS | MEM Memphis, TN | Express Airlines |
| PNS | MGM Montgomery, AL | Express Airlines |
| PNS | MLU Monroe, LA | Express Airlines |
| PNS | MOB Mobile, AL | Express Airlines |
| PNS | MSL Muscle Shoals, AL | Express Airlines |
| PNS | PAH Paducah, KY | Express Airlines |
| PNS | PIB Laurel, MS | Express Airlines |
| PNS | SDF Louisville, KY | Express Airlines |
| PNS | SGF Springfield, MO | Express Airlines |
| PNS | SHV Shreveport, LA | Express Airlines |
| PNS | SPI Springfield, IL | Express Airlines |
| PNS | TRI Kingsport, TN | Express Airlines |
| PNS | TUL Tulsa, OK | Express Airlines |
| PNS | TUP Tupelo, MS | Express Airlines |
| PNS | TYS Knoxville, TN | Express Airlines |
| PNS | EYW Key West, FL | Piedmont Airlines |
| PNS | JAX Jacksonville, FL | Piedmont Airlines |
| PNS | MIA Miami, FL | Piedmont Airlines |
| PNS | PBI West Palm Beach, FL | Piedmont Airlines |
| PNS | TLH Tallahassee, FL | Piedmont Airlines |
| PNS | TPA Tampa, FL | Piedmont Airlines |
| PNS | DFW Dallas/Fort Worth, TX | Sky West Airlines, Inc. |
| PNS | IAH Houston, TX | Sky West Airlines, Inc. |
| PNS | DCA Washington, DC, DC US | US Airways |
| PNS | JFK New York City, NY US | US Airways |
| PNS | LGA New York City, NY US | US Airways |
There is over 73 domestic flights from PNS airport.
