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Domestic Scheduled Flights
| Origin | Destination | Carier |
| MDW | ACT Waco, TX US | |
| MDW | CLL College Station, TX US | |
| MDW | DRO Durango, CO US | |
| MDW | EWN New Bern, NC US | |
| MDW | JAC Jackson, WY US | |
| MDW | LRD Laredo, TX US | |
| MDW | OAJ Richlands, NC US | |
| MDW | SBA Santa Barbara, CA US | |
| MDW | SBP San Luis Obispo, CA US | |
| MDW | SGF Springfield, MO US | |
| MDW | ASE Aspen, CO US | |
| MDW | BFL Bakersfield, CA US | |
| MDW | DAB Daytona Beach, FL US | AirTran Airways |
| MDW | GPT Gulfport, MS US | AirTran Airways |
| MDW | HOU Houston, TX US | AirTran Airways |
| MDW | JAX Jacksonville, FL US | AirTran Airways |
| MDW | LGA New York City, NY US | AirTran Airways |
| MDW | MCO Orlando, FL US | AirTran Airways |
| MDW | MEM Memphis, TN US | AirTran Airways |
| MDW | MIA Miami, FL US | AirTran Airways |
| MDW | MSP St. Paul, MN US | AirTran Airways |
| MDW | MSY New Orleans, LA US | AirTran Airways |
| MDW | PBI West Palm Beach, FL US | AirTran Airways |
| MDW | PHF Newport News / Williamsburg / Hampton, VA US | AirTran Airways |
| MDW | PNS Pensacola, FL US | AirTran Airways |
| MDW | RDU Raleigh - Durham, NC US | AirTran Airways |
| MDW | RIC Richmond, VA US | AirTran Airways |
| MDW | RSW Fort Myers, FL US | AirTran Airways |
| MDW | SAV Savannah, GA US | AirTran Airways |
| MDW | SRQ Sarasota - Bradenton, FL US | AirTran Airways |
| MDW | SWF Newburgh / Poughkeepsie, NY US | AirTran Airways |
| MDW | ATL Atlanta,, GA US | AirTran Airways |
| MDW | BOS Boston, MA US | AirTran Airways |
| MDW | CLT Charlotte, NC US | AirTran Airways |
| MDW | COS Colorado Springs, CO US | American Airlines |
| MDW | FAT Fresno, CA US | American Airlines |
| MDW | FLL Fort Lauderdale, FL US | American Airlines |
| MDW | GRK Fort Hood, TX US | American Airlines |
| MDW | HDN Hayden, CO US | American Airlines |
| MDW | IAH Houston, TX US | American Airlines |
| MDW | JAC Jackson, WY US | American Airlines |
| MDW | LBB Lubbock, TX US | American Airlines |
| MDW | LGB Long Beach, CA US | American Airlines |
| MDW | LRD Laredo, TX US | American Airlines |
| MDW | MFE Mc Allen / Mission, TX US | American Airlines |
| MDW | MTJ Montrose, CO US | American Airlines |
| MDW | OKC Oklahoma City, OK US | American Airlines |
| MDW | ONT Ontario, CA US | American Airlines |
| MDW | PHX Phoenix, AZ US | American Airlines |
| MDW | PSP Palm Springs, CA US | American Airlines |
| MDW | SAT San Antonio, TX US | American Airlines |
| MDW | SHV Shreveport, LA US | American Airlines |
| MDW | TUS Tucson, AZ US | American Airlines |
| MDW | TYR Tyler, TX US | American Airlines |
| MDW | XNA Fayetteville, AR US | American Airlines |
| MDW | AMA Amarillo, TX US | American Airlines |
| MDW | BTR Baton Rouge, LA US | American Airlines |
| MDW | BUR Burbank, CA US | American Airlines |
| MDW | DAY Dayton, OH US | ATA Airlines |
| MDW | DCA Washington, DC, DC US | ATA Airlines |
| MDW | DEN Denver, CO US | ATA Airlines |
| MDW | DFW Dallas / Ft Worth, TX US | ATA Airlines |
| MDW | DSM Des Moines, IA US | ATA Airlines |
| MDW | EVV Evansville, IN US | ATA Airlines |
| MDW | EWR Newark, NJ US | ATA Airlines |
| MDW | FNT Flint, MI US | ATA Airlines |
| MDW | FWA Ft. Wayne, IN US | ATA Airlines |
| MDW | GRR Grand Rapids, MI US | ATA Airlines |
| MDW | LAS Las Vegas, NV US | ATA Airlines |
| MDW | LAX Los Angeles, CA US | ATA Airlines |
| MDW | LGA New York City, NY US | ATA Airlines |
| MDW | MCO Orlando, FL US | ATA Airlines |
| MDW | MIA Miami, FL US | ATA Airlines |
| MDW | MKE Milwaukee, WI US | ATA Airlines |
| MDW | MLI Moline, IL US | ATA Airlines |
| MDW | MSN Madison, WI US | ATA Airlines |
| MDW | MSP St. Paul, MN US | ATA Airlines |
| MDW | PIE St Petersburg - Clearwater, FL US | ATA Airlines |
| MDW | PIT Pittsburgh, PA US | ATA Airlines |
| MDW | RSW Fort Myers, FL US | ATA Airlines |
| MDW | SEA Seattle, WA US | ATA Airlines |
| MDW | SFO San Francisco, CA US | ATA Airlines |
| MDW | SPI Springfield, IL US | ATA Airlines |
| MDW | SRQ Sarasota - Bradenton, FL US | ATA Airlines |
| MDW | TOL Toledo, OH US | ATA Airlines |
| MDW | BOS Boston, MA US | ATA Airlines |
| MDW | CLT Charlotte, NC US | ATA Airlines |
| MDW | SPI Springfield, IL US | Big Sky Airlines |
| MDW | AVP Wilkes Barre / Scranton, PA US | Continental Airlines |
| MDW | CVG Cincinnati, KY US | Continental Airlines |
| MDW | DAY Dayton, OH US | Continental Airlines |
| MDW | ERI Erie, PA US | Continental Airlines |
| MDW | EWR Newark, NJ US | Continental Airlines |
| MDW | EYW Key West, FL US | Continental Airlines |
| MDW | HPN Westchester County, NY US | Continental Airlines |
| MDW | LEX Lexington, KY US | Continental Airlines |
| MDW | MDT Harrisburg, PA US | Continental Airlines |
| MDW | ORF Norfolk, VA US | Continental Airlines |
| MDW | PHL Philadelphia, PA US | Continental Airlines |
| MDW | PWM Portland, ME US | Continental Airlines |
| MDW | RIC Richmond, VA US | Continental Airlines |
| MDW | ROC Rochester, NY US | Continental Airlines |
| MDW | SYR Syracuse, NY US | Continental Airlines |
| MDW | TYS Alcoa, TN US | Continental Airlines |
| MDW | ABE Allentown, PA US | Continental Airlines |
| MDW | BTV Burlington, VT US | Continental Airlines |
| MDW | CHS Charleston, SC US | Continental Airlines |
| MDW | CRW Charleston, WV US | Continental Airlines |
| MDW | CAE Columbia, SC US | Delta Air Lines |
| MDW | COS Colorado Springs, CO US | Delta Air Lines |
| MDW | CVG Cincinnati, KY US | Delta Air Lines |
| MDW | DAB Daytona Beach, FL US | Delta Air Lines |
| MDW | EYW Key West, FL US | Delta Air Lines |
| MDW | FAY Fayetteville, NC US | Delta Air Lines |
| MDW | GPI Kalispell Glacier Park International, MT US | Delta Air Lines |
| MDW | FLL Fort Lauderdale, FL US | Delta Air Lines |
| MDW | FSD Sioux Falls, SD US | Delta Air Lines |
| MDW | GNV Gainesville, FL US | Delta Air Lines |
| MDW | GRK Fort Hood, TX US | Delta Air Lines |
| MDW | GSO Greensboro - High Point, NC US | Delta Air Lines |
| MDW | GSP Greer, SC US | Delta Air Lines |
| MDW | HOU Houston, TX US | Delta Air Lines |
| MDW | HSV Huntsville - Decatur, AL US | Delta Air Lines |
| MDW | IAD Washington, DC, DC US | Delta Air Lines |
| MDW | ICT Wichita, KS US | Delta Air Lines |
| MDW | ILM Wilmington, NC US | Delta Air Lines |
| MDW | JAN Jackson, MS US | Delta Air Lines |
| MDW | JFK New York City, NY US | Delta Air Lines |
| MDW | LEX Lexington, KY US | Delta Air Lines |
| MDW | LFT Lafayette, LA US | Delta Air Lines |
| MDW | LIT Little Rock, AR US | Delta Air Lines |
| MDW | MEM Memphis, TN US | Delta Air Lines |
| MDW | MFE Mc Allen / Mission, TX US | Delta Air Lines |
| MDW | MGM Montgomery, AL US | Delta Air Lines |
| MDW | MLB Melbourne, FL US | Delta Air Lines |
| MDW | MLU Monroe, LA US | Delta Air Lines |
| MDW | MOB Mobile, AL US | Delta Air Lines |
| MDW | MYR Myrtle Beach, SC US | Delta Air Lines |
| MDW | OAJ Richlands, NC US | Delta Air Lines |
| MDW | ONT Ontario, CA US | Delta Air Lines |
| MDW | ORF Norfolk, VA US | Delta Air Lines |
| MDW | PFN Panama City, FL US | Delta Air Lines |
| MDW | PSP Palm Springs, CA US | Delta Air Lines |
| MDW | RDU Raleigh - Durham, NC US | Delta Air Lines |
| MDW | RIC Richmond, VA US | Delta Air Lines |
| MDW | ROA Roanoke, VA US | Delta Air Lines |
| MDW | RSW Fort Myers, FL US | Delta Air Lines |
| MDW | SAT San Antonio, TX US | Delta Air Lines |
| MDW | UNV State College, PA US | Delta Air Lines |
| MDW | SFO San Francisco, CA US | Delta Air Lines |
| MDW | SGF Springfield, MO US | Delta Air Lines |
| MDW | SHV Shreveport, LA US | Delta Air Lines |
| MDW | SRQ Sarasota - Bradenton, FL US | Delta Air Lines |
| MDW | TLH Tallahassee, FL US | Delta Air Lines |
| MDW | TPA Tampa, FL US | Delta Air Lines |
| MDW | TYS Alcoa, TN US | Delta Air Lines |
| MDW | VPS Valparaiso, FL US | Delta Air Lines |
| MDW | ABE Allentown, PA US | Delta Air Lines |
| MDW | AEX Alexandria, LA US | Delta Air Lines |
| MDW | AGS Augusta, GA US | Delta Air Lines |
| MDW | AVL Asheville - Hendersonville, NC US | Delta Air Lines |
| MDW | BGR Bangor, ME US | Delta Air Lines |
| MDW | BHM Birmingham, AL US | Delta Air Lines |
| MDW | BTR Baton Rouge, LA US | Delta Air Lines |
| MDW | BTV Burlington, VT US | Delta Air Lines |
| MDW | BZN Belgrade, MT US | Delta Air Lines |
| MDW | CHA Chattanooga, TN US | Delta Air Lines |
| MDW | CHO Charlottesville, VA US | Delta Air Lines |
| MDW | CHS Charleston, SC US | Delta Air Lines |
| MDW | CLT Charlotte, NC US | Delta Air Lines |
| MDW | CRW Charleston, WV US | Delta Air Lines |
| MDW | TRI Bristol / Johnson City / Kingsport, TN US | Delta Air Lines |
| MDW | DEN Denver, CO US | Frontier Airlines |
| MDW | ELP El Paso, TX US | Frontier Airlines |
| MDW | FAT Fresno, CA US | Frontier Airlines |
| MDW | GEG Spokane, WA US | Frontier Airlines |
| MDW | LAS Las Vegas, NV US | Frontier Airlines |
| MDW | LAX Los Angeles, CA US | Frontier Airlines |
| MDW | OKC Oklahoma City, OK US | Frontier Airlines |
| MDW | PDX Portland, OR US | Frontier Airlines |
| MDW | PHX Phoenix, AZ US | Frontier Airlines |
| MDW | RNO Reno, NV US | Frontier Airlines |
| MDW | SAN San Diego, CA US | Frontier Airlines |
| MDW | SEA Seattle, WA US | Frontier Airlines |
| MDW | SFO San Francisco, CA US | Frontier Airlines |
| MDW | SJC San Jose, CA US | Frontier Airlines |
| MDW | SLC Salt Lake City, UT US | Frontier Airlines |
| MDW | SMF Sacramento, CA US | Frontier Airlines |
| MDW | SNA Santa Ana - Orange County, CA US | Frontier Airlines |
| MDW | TEX Telluride, CO US | Frontier Airlines |
| MDW | TUS Tucson, AZ US | Frontier Airlines |
| MDW | ABQ Albuquerque, NM US | Frontier Airlines |
| MDW | AUS Austin, TX US | Frontier Airlines |
| MDW | BOI Boise, ID US | Frontier Airlines |
| MDW | BDL Hartford, CT US | Northwest Airlines |
| MDW | CAE Columbia, SC US | Northwest Airlines |
| MDW | COS Colorado Springs, CO US | Northwest Airlines |
| MDW | CVG Cincinnati, KY US | Northwest Airlines |
| MDW | CWA Wausau, WI US | Northwest Airlines |
| MDW | DLH Duluth, MN US | Northwest Airlines |
| MDW | DSM Des Moines, IA US | Northwest Airlines |
| MDW | DTW Detroit, MI US | Northwest Airlines |
| MDW | EGE Vail - Eagle, CO US | Northwest Airlines |
| MDW | ELM Elmira / Corning, NY US | Northwest Airlines |
| MDW | ERI Erie, PA US | Northwest Airlines |
| MDW | EUG Eugene, OR US | Northwest Airlines |
| MDW | FAR Fargo, ND US | Northwest Airlines |
| MDW | GPI Kalispell Glacier Park International, MT US | Northwest Airlines |
| MDW | FNT Flint, MI US | Northwest Airlines |
| MDW | FSD Sioux Falls, SD US | Northwest Airlines |
| MDW | GRR Grand Rapids, MI US | Northwest Airlines |
| MDW | GSO Greensboro - High Point, NC US | Northwest Airlines |
| MDW | GSP Greer, SC US | Northwest Airlines |
| MDW | HDN Hayden, CO US | Northwest Airlines |
| MDW | HPN Westchester County, NY US | Northwest Airlines |
| MDW | IAD Washington, DC, DC US | Northwest Airlines |
| MDW | IAH Houston, TX US | Northwest Airlines |
| MDW | ICT Wichita, KS US | Northwest Airlines |
| MDW | JFK New York City, NY US | Northwest Airlines |
| MDW | LAN Lansing, MI US | Northwest Airlines |
| MDW | LEX Lexington, KY US | Northwest Airlines |
| MDW | LFT Lafayette, LA US | Northwest Airlines |
| MDW | LNK Lincoln, NE US | Northwest Airlines |
| MDW | LSE La Crosse, WI US | Northwest Airlines |
| MDW | MBS Midland - Bay City - Saginaw, MI US | Northwest Airlines |
| MDW | MDT Harrisburg, PA US | Northwest Airlines |
| MDW | MFR Medford, OR US | Northwest Airlines |
| MDW | MHT Manchester, NH US | Northwest Airlines |
| MDW | MLU Monroe, LA US | Northwest Airlines |
| MDW | MOB Mobile, AL US | Northwest Airlines |
| MDW | MSO Missoula, MT US | Northwest Airlines |
| MDW | MSP St. Paul, MN US | Northwest Airlines |
| MDW | PHL Philadelphia, PA US | Northwest Airlines |
| MDW | PSP Palm Springs, CA US | Northwest Airlines |
| MDW | PVD Providence, RI US | Northwest Airlines |
| MDW | PWM Portland, ME US | Northwest Airlines |
| MDW | RAP Rapid City, SD US | Northwest Airlines |
| MDW | ROA Roanoke, VA US | Northwest Airlines |
| MDW | ROC Rochester, NY US | Northwest Airlines |
| MDW | RST Rochester, MN US | Northwest Airlines |
| MDW | UNV State College, PA US | Northwest Airlines |
| MDW | SGF Springfield, MO US | Northwest Airlines |
| MDW | SLC Salt Lake City, UT US | Northwest Airlines |
| MDW | SWF Newburgh / Poughkeepsie, NY US | Northwest Airlines |
| MDW | SYR Syracuse, NY US | Northwest Airlines |
| MDW | TOL Toledo, OH US | Northwest Airlines |
| MDW | TUL Tulsa, OK US | Northwest Airlines |
| MDW | TVC Traverse City, MI US | Northwest Airlines |
| MDW | VPS Valparaiso, FL US | Northwest Airlines |
| MDW | XNA Fayetteville, AR US | Northwest Airlines |
| MDW | ABE Allentown, PA US | Northwest Airlines |
| MDW | AEX Alexandria, LA US | Northwest Airlines |
| MDW | ALB Albany, NY US | Northwest Airlines |
| MDW | ASE Aspen, CO US | Northwest Airlines |
| MDW | AVL Asheville - Hendersonville, NC US | Northwest Airlines |
| MDW | BGM Binghamton / Endicott / Johnson City, NY US | Northwest Airlines |
| MDW | BIL Billings, MT US | Northwest Airlines |
| MDW | BIS Bismarck, ND US | Northwest Airlines |
| MDW | BTR Baton Rouge, LA US | Northwest Airlines |
| MDW | BUF Buffalo, NY US | Northwest Airlines |
| MDW | BWI Baltimore, MD US | Northwest Airlines |
| MDW | BZN Belgrade, MT US | Northwest Airlines |
| MDW | CAK Akron / Canton, OH US | Northwest Airlines |
| MDW | CHO Charlottesville, VA US | Northwest Airlines |
| MDW | CHS Charleston, SC US | Northwest Airlines |
| MDW | CLT Charlotte, NC US | Northwest Airlines |
| MDW | CRW Charleston, WV US | Northwest Airlines |
| MDW | TRI Bristol / Johnson City / Kingsport, TN US | Northwest Airlines |
| MDW | BDL Hartford, CT US | Southwest Airlines |
| MDW | BNA Nashville, TN US | Southwest Airlines |
| MDW | CLE Cleveland, OH US | Southwest Airlines |
| MDW | CMH Columbus, OH US | Southwest Airlines |
| MDW | CRP Corpus Christi, TX US | Southwest Airlines |
| MDW | DAL Dallas, TX US | Southwest Airlines |
| MDW | DCA Washington, DC, DC US | Southwest Airlines |
| MDW | DTW Detroit, MI US | Southwest Airlines |
| MDW | ELP El Paso, TX US | Southwest Airlines |
| MDW | FLL Fort Lauderdale, FL US | Southwest Airlines |
| MDW | GEG Spokane, WA US | Southwest Airlines |
| MDW | HOU Houston, TX US | Southwest Airlines |
| MDW | HRL Harlingen, TX US | Southwest Airlines |
| MDW | IAD Washington, DC, DC US | Southwest Airlines |
| MDW | IND Indianapolis, IN US | Southwest Airlines |
| MDW | ISP Islip, NY US | Southwest Airlines |
| MDW | JAN Jackson, MS US | Southwest Airlines |
| MDW | JAX Jacksonville, FL US | Southwest Airlines |
| MDW | LAS Las Vegas, NV US | Southwest Airlines |
| MDW | LAX Los Angeles, CA US | Southwest Airlines |
| MDW | LBB Lubbock, TX US | Southwest Airlines |
| MDW | LIT Little Rock, AR US | Southwest Airlines |
| MDW | MAF Midland / Odessa, TX US | Southwest Airlines |
| MDW | MCI Kansas City, MO US | Southwest Airlines |
| MDW | MCO Orlando, FL US | Southwest Airlines |
| MDW | MHT Manchester, NH US | Southwest Airlines |
| MDW | MSY New Orleans, LA US | Southwest Airlines |
| MDW | OAK Oakland, CA US | Southwest Airlines |
| MDW | OKC Oklahoma City, OK US | Southwest Airlines |
| MDW | OMA Omaha, NE US | Southwest Airlines |
| MDW | ONT Ontario, CA US | Southwest Airlines |
| MDW | ORF Norfolk, VA US | Southwest Airlines |
| MDW | PBI West Palm Beach, FL US | Southwest Airlines |
| MDW | PDX Portland, OR US | Southwest Airlines |
| MDW | PHL Philadelphia, PA US | Southwest Airlines |
| MDW | PHX Phoenix, AZ US | Southwest Airlines |
| MDW | PIT Pittsburgh, PA US | Southwest Airlines |
| MDW | PVD Providence, RI US | Southwest Airlines |
| MDW | RDU Raleigh - Durham, NC US | Southwest Airlines |
| MDW | RNO Reno, NV US | Southwest Airlines |
| MDW | RSW Fort Myers, FL US | Southwest Airlines |
| MDW | SAN San Diego, CA US | Southwest Airlines |
| MDW | SAT San Antonio, TX US | Southwest Airlines |
| MDW | SDF Louisville, KY US | Southwest Airlines |
| MDW | SEA Seattle, WA US | Southwest Airlines |
| MDW | SJC San Jose, CA US | Southwest Airlines |
| MDW | SLC Salt Lake City, UT US | Southwest Airlines |
| MDW | SMF Sacramento, CA US | Southwest Airlines |
| MDW | SNA Santa Ana - Orange County, CA US | Southwest Airlines |
| MDW | STL St Louis, MO US | Southwest Airlines |
| MDW | TPA Tampa, FL US | Southwest Airlines |
| MDW | TUL Tulsa, OK US | Southwest Airlines |
| MDW | TUS Tucson, AZ US | Southwest Airlines |
| MDW | ABQ Albuquerque, NM US | Southwest Airlines |
| MDW | ALB Albany, NY US | Southwest Airlines |
| MDW | AMA Amarillo, TX US | Southwest Airlines |
| MDW | AUS Austin, TX US | Southwest Airlines |
| MDW | BHM Birmingham, AL US | Southwest Airlines |
| MDW | BOI Boise, ID US | Southwest Airlines |
| MDW | BUF Buffalo, NY US | Southwest Airlines |
| MDW | BUR Burbank, CA US | Southwest Airlines |
| MDW | BWI Baltimore, MD US | Southwest Airlines |
There is over 330 domestic flights from MDW airport.
