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Domestic Scheduled Flights
| Origin | Destination | Carier |
| ESC | BDL Windsor Locks, CT | Astral Aviation |
| ESC | BNA Nashville, TN | Astral Aviation |
| ESC | BWI Baltimore, MD | Astral Aviation |
| ESC | CLE Cleveland, OH | Astral Aviation |
| ESC | CMH Columbus, OH | Astral Aviation |
| ESC | CVG Cincinnati, OH | Astral Aviation |
| ESC | DAY Dayton, OH | Astral Aviation |
| ESC | DSM Des Moines, IA | Astral Aviation |
| ESC | FNT Flint, MI | Astral Aviation |
| ESC | GRR Grand Rapids, MI | Astral Aviation |
| ESC | IAD Washington, DC | Astral Aviation |
| ESC | IND Indianapolis, IN | Astral Aviation |
| ESC | LAN Lansing, MI | Astral Aviation |
| ESC | LSE La Crosse, WI | Astral Aviation |
| ESC | MKE Milwaukee, WI | Astral Aviation |
| ESC | MLI Moline, IL | Astral Aviation |
| ESC | MQT Marquette, MI | Astral Aviation |
| ESC | MSN Madison, WI | Astral Aviation |
| ESC | MSP Minneapolis, MN | Astral Aviation |
| ESC | PHL Philadelphia, PA | Astral Aviation |
| ESC | PIT Pittsburgh, PA | Astral Aviation |
| ESC | RDU Raleigh/Durham, NC | Astral Aviation |
| ESC | SDF Louisville, KY | Astral Aviation |
| ESC | STL St. Louis, MO | Astral Aviation |
There is over 24 domestic flights from ESC airport.
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